MassGeneral Institute of Neurodegenerative Disease                                Massachusetts General Hospital   Harvard Medical School

Brian Bacskai Lab - Optical Imaging Approaches for Alzheimer's Disease

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Dense core plaques activate the fluorogenic activator Amplex Red in-vivo (A).  Histochemical marker ThioFlavin-S confirms the presence of the dense core plaque (C).  McLellan et. al.

Imaging of an intact mouse brain from a 22 month Tg2576 mouse imaged after staining with ThioFlavin-S.  By 22 months, Tg2576 mice develop extensive CAA.  Domnitz et. al.

Noninvasive detection of NIR fluorescence in vivo in the brain of an intact mouse.  An injection of Alexa fluor 750-labeled BAM-10 antibody was made in an anesthetized mouse in the right hemisphere several millimeters deep from the cortical surface.  The skin was restored and sutured close along the midline.  The imaging of the anesthetized mouse was performed through skin and skull with (a) the eXplore Optix and (b) the LI-COR Odyssey.  The postmortem brain was also imaged using the LI-COR Odyssey (c).  Skoch et. al.